ECS and Mental Health


  • The ECS has a major impact on the mental health of individuals across a wide spectrum of mental health issues.

  • There has been an explosion in mental health issues that can be partially attributed to the western diet that is high in omega 6 based foods

    • The higher the omega 6 content in food, the less omega 3 that gets used by the body.

      • The balance of closer to 3-1 balance of omega 6 to omega 3 is needed for proper ECS activation.

  • Mental health diseases such as ADHD, depression, and PTSD are affected by the ECS.

  • Stress exposure has been shown to reduce endocannabinoid levels of AEA and increase 2-AG levels.

    • Exposure to chronic stress causes a downregulation, or loss, of CB1 receptors.

  • Studies have shown that the decline in AEA appears to contribute to the manifestation of the stress response, including activation of the hypothalamic-pituitary-adrenal (HPA) axis and increases in anxiety behavior.

    • This shows why activation of the ECS through exercise, which produces AEA in the body, is so effective for mental health disorders.


Loren DeFalco, President


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