ECS and Drug and Alcohol Addiction


  • The ECS plays a role in drug addiction to various substances through interaction with the ECS receptors.

  • Brain cannabinoid CB2 receptors modulate cocaine’s actions in mice.

    • These findings suggest that brain CB2 receptors may represent a novel target for cocaine and other drug addictions.

  • CBD and THC at high doses increased the likelihood of extinction of cocaine- and amphetamine-induced conditioned preference in rats.

  • CBD in rats attenuated heroin-seeking behavior by conditioned stimuli, even after a lapse of 2 weeks.

  • Recent human studies have demonstrated that volunteers smoking cannabis with higher CBD content reduced their desire for drug-related stimuli.

    • The authors suggested that CBD can modulate reinforcing properties of drugs of abuse and help in training to reduce relapse to alcoholism.

  • Interestingly there is a connection with alcohol and concentration of EPA and DHA (omega 3 found in fish oil).

    • Although there is no correlation with spirits and beer, wine has been found to correlate to higher concentrations of EPA/DHA in plasma and red blood cell membranes.


ECS and Nicotine

  • A new study shows that nicotine exposure leads to the release of lipids called endocannabinoids that affect dopamine-producing neurons.

  • Blocking the production of the body's endocannabinoid 2-AG affects the motivation to consume nicotine.


Loren DeFalco, President


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